GHRP-6 10mg
$39.99
GHRP-6 | 10mg | Research Peptide
What is GHRP-6?
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and first-generation growth hormone secretagogue (GHS) consisting of six amino acids — His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂. As the original and most extensively studied member of the GHRP peptide family, GHRP-6 holds a foundational position in growth hormone research and was instrumental in establishing the existence of the growth hormone secretagogue receptor (GHSR-1a) — a discovery that ultimately led to the identification of ghrelin as an endogenous ligand for this receptor class. GHRP-6 functions by selectively binding to GHSR-1a receptors located in both the pituitary gland and the hypothalamus, stimulating a strong and dose-dependent release of endogenous growth hormone (GH).
First synthesized and studied in the 1980s, GHRP-6 was among the earliest synthetic peptides demonstrated to potently stimulate GH release independent of growth hormone releasing hormone (GHRH) pathways, though it exhibits significant synergy when co-administered with GHRH analogs. One of GHRP-6's most well-documented characteristics is its notable activation of ghrelin receptor pathways, which produces a pronounced appetite-stimulating effect in animal models — a property that distinguishes it from later generation GHS peptides such as GHRP-2 and Ipamorelin. This appetite stimulation effect has itself become a subject of dedicated research interest in the study of energy homeostasis, gastric motility, and ghrelin biology. Beyond its primary GH-stimulating mechanism, GHRP-6 has also been studied for its cytoprotective, anti-inflammatory, and tissue repair properties across a broad range of preclinical models, establishing it as one of the most versatile and historically significant peptides in GH and metabolic research.
Overview
GHRP-6 is the original first-generation synthetic growth hormone secretagogue, historically significant as the compound that led to the discovery of the GHSR-1a receptor and the endogenous hormone ghrelin. Its potent GH-stimulating properties, pronounced ghrelin receptor activation, and well-established synergy with GHRH analogs have made it a cornerstone research tool in growth hormone biology, appetite regulation, cytoprotection, and metabolic science.
Product Details
Peptide: GHRP-6 (Growth Hormone Releasing Peptide-6)
Type: Growth Hormone Releasing Peptide / Growth Hormone Secretagogue (GHS) / Hexapeptide
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
Molecular Formula: C₄₆H₅₆N₁₂O₆
Molecular Weight: 873.02 g/mol
CAS Number: 87616-84-0
Quantity: 10mg
Appearance: Lyophilized white powder
Purity: ≥99% (HPLC verified)
Reconstitution Fluid: Bacteriostatic Water (BW) or Sterile Saline (0.9% NaCl)
Storage: Store lyophilized peptide at -20°C. Upon reconstitution, store at 4°C and use within 30 days. Avoid repeated freeze-thaw cycles. Protect from light.
Research Applications
GHRP-6 has been extensively studied in preclinical models for its potential roles in:
Growth Hormone Secretion Research — Investigated for its potent and dose-dependent stimulation of pulsatile GH release via GHSR-1a receptor activation in anterior pituitary and hypothalamic tissue models, establishing it as one of the most powerful GH-stimulating peptides in the GHS class.
Ghrelin Receptor Biology — As the compound instrumental in identifying the GHSR-1a receptor, GHRP-6 remains a primary research tool for studying ghrelin receptor signaling, ligand binding dynamics, and downstream pathway activation.
GHRH Synergy Studies — Studied extensively for its synergistic amplification of GH release when co-administered with growth hormone releasing hormone (GHRH) analogs such as CJC-1295, producing significantly greater GH output than either compound alone.
Appetite & Energy Homeostasis Research — GHRP-6's pronounced activation of ghrelin receptor pathways produces a well-documented appetite-stimulating effect in animal models, making it a valuable tool for studying energy balance, food intake regulation, and gastric motility.
IGF-1 Regulation Research — Investigated for its downstream influence on insulin-like growth factor-1 (IGF-1) production in hepatic tissue models, a primary mediator of GH's anabolic, regenerative, and metabolic effects.
Cytoprotective Research — Preclinical studies have extensively investigated GHRP-6's cytoprotective properties, particularly in cardiac, hepatic, and skeletal muscle tissue models subjected to ischemic, toxic, or oxidative stress conditions.
Anti-Inflammatory Research — Studied for its potential to modulate inflammatory cytokine expression and reduce systemic inflammatory markers, with particular interest in NF-κB pathway modulation in in vivo research models.
Tissue Repair & Wound Healing — Research has examined GHRP-6's influence on fibroblast activation, collagen synthesis, and wound contraction in preclinical tissue repair models, independent of its GH-stimulating properties.
Body Composition Research — Preclinical models have explored GHRP-6's potential effects on lean muscle preservation, lipolysis, and overall body composition through GH and IGF-1 mediated anabolic signaling pathways.
Anti-Aging & Longevity Research — As one of the earliest and most studied GHS peptides, GHRP-6 continues to be used as a research tool for investigating GH restoration strategies and their effects on age-related metabolic, musculoskeletal, and physiological decline.
Research Notes
GHRP-6 is a research chemical intended strictly for laboratory and in vitro/in vivo research use only. It is not approved for human consumption, therapeutic use, or veterinary application. All data and findings referenced are sourced from peer-reviewed preclinical studies.
Handling & Reconstitution (For Research Use)
For research purposes, GHRP-6 lyophilized powder is typically reconstituted using bacteriostatic water or sterile saline. Add reconstitution fluid slowly by directing it to the side of the vial and swirling gently — do not shake. Handle under sterile conditions and avoid repeated freeze-thaw cycles to maintain peptide integrity and potency. Protect reconstituted solution from direct light exposure.
Disclaimer
This product is sold for research and laboratory use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. Must be handled by qualified researchers in accordance with all applicable laws and regulations.