DSIP 5mg
$24.99
DSIP | 5mg | Research Peptide
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide consisting of nine amino acids — Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — first isolated from the cerebral venous blood of rabbits in 1974 by Swiss researchers Monnier and Schoenenberger. As its name suggests, DSIP was originally identified for its ability to induce delta-wave sleep patterns in animal models when administered directly into the thalamic region of the brain. However, subsequent decades of research have revealed a far broader and more complex biological profile than its name implies, establishing DSIP as one of the most multifunctional neuropeptides studied in modern neuroscience and endocrinology.
DSIP is found naturally in both the central and peripheral nervous systems, as well as in the hypothalamus, pituitary gland, and various peripheral tissues including the gut, pancreas, and adrenal glands. Its widespread distribution across biological systems has fueled research interest well beyond sleep biology, encompassing stress response modulation, neuroendocrine regulation, antioxidant activity, and circadian rhythm research. One of DSIP's most distinctive characteristics is its ability to cross the blood-brain barrier — a property that is exceptionally rare among peptides of its size and has made it particularly valuable as a research tool for studying central nervous system peptide signaling. Its natural occurrence, broad tissue distribution, and diverse biological activity profile have established DSIP as a uniquely versatile neuropeptide in preclinical research.
Overview
DSIP is a naturally occurring nonapeptide neuropeptide first identified for its delta sleep-inducing properties and subsequently studied across a broad range of biological systems. Its ability to cross the blood-brain barrier, combined with its widespread distribution in both central and peripheral tissues, has made it a valuable research tool in neuroscience, endocrinology, stress biology, and circadian rhythm research.
Product Details
Peptide: DSIP (Delta Sleep-Inducing Peptide)
Type: Neuropeptide / Nonapeptide
Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Formula: C₃₅H₄₈N₁₀O₁₅
Molecular Weight: 848.81 g/mol
CAS Number: 62568-57-4
Quantity: 5mg
Appearance: Lyophilized white powder
Purity: ≥99% (HPLC verified)
Reconstitution Fluid: Bacteriostatic Water (BW) or Sterile Saline (0.9% NaCl)
Storage: Store lyophilized peptide at -20°C. Upon reconstitution, store at 4°C and use within 30 days. Avoid repeated freeze-thaw cycles. Protect from light.
Research Applications
DSIP has been extensively studied in preclinical models for its potential roles in:
Sleep & Delta Wave Research — Investigated for its original and most well-documented property of inducing delta-wave sleep patterns in animal models, making it a primary research tool in sleep architecture, sleep stage modulation, and insomnia-related studies.
Circadian Rhythm Research — Studied for its role in regulating circadian rhythm patterns and sleep-wake cycle dynamics, with particular interest in its influence on biological clock synchronization and chronobiological disruption models.
Stress Response Modulation — Preclinical research has explored DSIP's capacity to normalize stress-induced physiological responses, including its effects on corticotropin release and hypothalamic-pituitary-adrenal (HPA) axis activity in stress models.
Neuroendocrine Regulation — Investigated for its influence on the release of multiple pituitary hormones including LH, GH, and TSH, suggesting a broad modulatory role within the hypothalamic-pituitary axis in animal models.
Antioxidant Research — Studies have examined DSIP's potential antioxidant properties, including its ability to reduce lipid peroxidation and reactive oxygen species (ROS) activity in neuronal and peripheral tissue models.
Pain & Analgesic Research — Preclinical models have explored DSIP's potential analgesic properties and its interaction with endogenous opioid systems, with research suggesting modulation of pain perception pathways in animal models.
Blood-Brain Barrier Peptide Transport Research — As one of the few peptides of its size capable of crossing the blood-brain barrier, DSIP is studied as a research model for investigating peptide transport mechanisms and CNS delivery strategies.
Withdrawal & Dependency Research — Preclinical studies have investigated DSIP's potential to modulate withdrawal symptoms and dependency-related physiological responses in animal models of substance dependence.
Oncological Research — Emerging preclinical research has explored DSIP's potential influence on tumor growth inhibition and its effects on abnormal cell proliferation in various cancer cell line models.
Research Notes
DSIP is a research chemical intended strictly for laboratory and in vitro/in vivo research use only. It is not approved for human consumption, therapeutic use, or veterinary application. All data and findings referenced are sourced from peer-reviewed preclinical studies.
Handling & Reconstitution (For Research Use)
For research purposes, DSIP lyophilized powder is typically reconstituted using bacteriostatic water or sterile saline. Add reconstitution fluid slowly by directing it to the side of the vial and swirling gently — do not shake. Handle under sterile conditions and avoid repeated freeze-thaw cycles to maintain peptide integrity and potency. Protect reconstituted solution from direct light exposure.
Disclaimer
This product is sold for research and laboratory use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. Must be handled by qualified researchers in accordance with all applicable laws and regulations.